The College of Pharmacy is pleased to announce the publication of an original research paper with sole authorship by its faculty member, Christiane Chbib, Pharm.D., Ph.D., Assistant Professor in the Department of Pharmaceutical Sciences.
The paper titled “Synthesis of isomeric analogues of S-ribosylhomocysteine analogues with homocysteine unit attached to C2 of ribose” has recently been published in Elsevier’s Bioorganic and Medicinal Chemistry Letters journal which publishes research communications of outstanding significance and timeliness on topics at the interface of chemistry and biology.
During the last few years, Dr. Chbib has been working on designing and synthesis of novel antibacterial agents with new mechanism of action and therapeutic classification. Dr. Chbib’s aforementioned publication is based on research carried out in collaboration with the Florida International University, Miami, FL, and involved the synthesis of novel isomeric analogues of S-ribosylhomocysteine in which the homocysteine moiety is attached to a ribose ring via C2-sulfur bond. These new molecules are expected to act as antibacterial agents by targeting the enzyme LuxS found in both Gram-positive and Gram-negative bacteria.
The full text of this publication may be accessed by clicking on the following link: http://www.sciencedirect.com/science/article/pii/S0960894X17302299