Research Profile

Dr. Nicole Lounsbury,

Dr. Lounsbury’s research interests are in the discovery and development of novel pharmaceuticals. Her academic research experience was focused on the design of novel antimicrobials for methicillin-resistant S. aureus and chalcone activators of Nrf2. Her research interests also include the development of inhibitors of CXCR7 for the treatment of lung cancer.

Selected Publications

Boylan, P.M.; Sedlacek, J.; Santibanez, M.; Church, A.F.; Lounsbury, N.; Nguyen, J. Development and Implementation of Interprofessional Relations Between a College of Pharmacy and Osteopathic Residency Programs in a Community Teaching Hospital. Journal of Pharmacy Technology. 2019, 36, 3-9.
Lounsbury, N.; Eidem, T.; Colquhoun, J.; Mateo, G.; Abou-Gharbia, M.; Dunman, P.M.; Childers, W. Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin. Bioorgan Med Chem Lett. 2018, 28, 1127-1131.
Kurimchak AM, Shelton C, Duncan KE, Johnson KJ, Brown J, O’Brien S, Gabbasov R, Fink LS, Li Y, Lounsbury N, Abou-Gharbia M, Childers WE, Connolly DC, Chernoff J, Peterson JR, Duncan JS. Resistance to BET bromodomain inhibitors is mediated by kinome reprogramming in ovarian cancer. Cell Reports 16: 1273-1286 (2016)

Lounsbury N, Mateo G, Jones B, Papaiahgari S, Thimmulappa RK, Teijaro C, Gordon J, Korzekwa K, Ye M, Allaway G, Abou-Gharbia M, Biswal S, Childers W. Heterocyclic chalcone activators of nuclear factor (eryhtoid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy. Bioorganic and Medicinal Chemistry 23: 5352-5359 (2015)

Eidem, TM, Lounsbury N, Emery JF, Bulger J, Smith A, Abou-Gharbia M, Childers W, Dunman PM. Small molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing. Antimicrobial Agents and Chemotherapy 59: 2016-2028 (2015)