Research Profile

Dr. Surabhi Shukla,
M.S., PhD

Assistant Professor
College of Pharmacy
Department of Pharmaceutical Sciences

Dr. Shukla has a long-standing interest in the field of Neuroscience more specifically in the process of neurodegeneration and neuroregeneration. Her research work involves studying the mechanisms of neurite outgrowth and identification of potential neurotrophic agents that could induce neuronal differentiation and neurite outgrowth, conferring therapeutic protection against neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. She screened various selective and non-selective HDAC inhibitors for induction of neuronal differentiation and studied their mechanism of action. Her work has resulted in development of a combined in vitro assay for simultaneous measurement of cytotoxicity and neurotrophic activity. She has also identified mechanism of action of vorinostat, a pan HDAC inhibitor in inducing neuronal differentiation in neuronal cell line. Dr. Shukla’s current research interest includes development of new formulations and novel drug delivery techniques to improve the ocular bioavailability of poorly soluble/permeating drugs that may play important role in treatment of ocular infections and retinal diseases.

Publications
Shukla S and Tekwani BL. Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation. Front. Pharmacol. 11:537 (2020)
Yadav KJ, Tatke A, Shukla S, Lamichhane SP, Avula B, Wang XD, Jablonski MM, Khan IA, Majumdar S. Retina compatible interactions and effective modulation of blood ocular barrier P-gp activity by third-generation inhibitors improves ocular penetration of loperamide. Journal of Pharmaceutical Sciences 107-8 :2128-2135 (2018)
Chaurasiya ND, Shukla S, Tekwani BL. A combined In vitro assay for evaluation of neurotrophic activity and cytotoxicity. SLAS Discovery 1-9 (2017)
Shukla S, Madar ZS, Walker LA, Tekwani BL Mechanism for neurotrophic action of vorinostat, a pan HDAC inhibitor. Molecular and Cellular Neurosciences 77: 11-20 (2016)
Nayak SK, Swain P, Nanda PK, Dash S, Shukla S, Meher PK, Maiti NK. Effect of endotoxin on immunity of Indian major carp, Labeo rohita. Fish and Shelfish Immunology. 24: 394-399 (2008)

Selected Presentations

Surabhi Shukla and Babu Lal Tekwani (2019). Role of Cyclic AMP in Suberoylanilide Hydroxamic Acid (SAHA) induced neurite outgrowth. AAPS PharmSci 360 meeting, San Antonio, Texas. November 3-6, 2020.
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Soumyajit Majumdar. Inhibition of Mrp1 Efflux Protein Activity at the Blood Ocular Barriers: Effect of Specific Inhibitor on Ocular Penetration of Fluorescein (2017) AAPS Annual meeting, San Diego, California. Nov 12-15, 2017.
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Bharathi Avula, Soumyajit Majumdar (2017) The Impact of P-gp on the Blood Ocular Transport of Paclitaxel: A comparative study using Wild Type and Mdr 1A Knock Out Sprague Dawley Rats. AAPS Annual meeting, San Diego, California. Nov 12-15, 2017.
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Bharathi Avula, Soumyajit Majumdar (2017) Improved Permeation of Paclitaxel Across the Blood Aqueous Barrier by Modulating P-gp Activity Using Specific Inhibitors. (2017) AAPS Annual meeting, Nov 12-15, 2017.
Babu Tekwani, Narayan Das Chaurasiya, Surabhi Shukla, Ilias Muhammad, Larry Walker Neurotrophic and Neuritogenic Drug Leads from Natural Products. A combined invitro assay for evaluation of cell viability and NGF stimulated neuritic outgrowth in Neuroscreeen-1 cells. International Conference on the Science of Botanicals, Oxford, MS. 2015.
Surabhi Shukla, Ilias Muhammad, Larry A Walker and Babu Lal Tekwani (2015). Evaluation of selective inhibitors of histone deacetylases as potential neurotrophic agents. ICSB meeting, Oxford, Mississippi. April 13-16, 2015
Surabhi Shukla, Ilias Muhammad, Larry A Walker and Babu Lal Tekwani (2014). Evaluation of inhibitors of Histone deacetylases as potential neurotrophic agents. ASP/ICSB meeting, Oxford, Mississippi. August 2-6, 2014
Surabhi Shukla, Ilias Muhammad, Larry A. Walker and Babu L. Tekwani (2014). Suberoylanilide Hydroxamic Acid (SAHA) induces neuritogeneisis and activates TrkA/MAPK pathways and hyperacetylation of α- Tubulin. NISBRE IDeA Symposium, Washington. DC. June 16-18, 2014.
Surabhi Shukla, Ilias Muhammad, Larry A. Walker and Babu L. Tekwani. (2014) Molecular and Cellular mechanisms for neurotrophic effects of Suberoylanilide Hydroxamic Acid (SAHA), a pan Histone Deacetylase (HDAC) Inhibitor. Graduate Student Council Research Forum, University of Mississippi, Oxford MS. April 17, 2014.
Surabhi Shukla, Larry A Walker and Babu Lal Tekwani (2013). In vitro neurotrophic properties of Suberoylanilide hydroxamic acid (SAHA), pan histone deacetylase inhibitor. Society for Neuroscience meeting. San Diego, California. Nov 9-13, 2013.

 
 
 
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