Christiane Chbib

Associate Professor College of Pharmacy
PharmD, PhD
Office: Room 2502
Phone: (305) 760 – 7478
Email: CChbib@ULarkin.org
Hours: By Appointment

B.S. | Lebanese American University | Beirut, Lebanon
Pharm.D. (ACPE-accredited program) | Lebanese American University | Beirut, Lebanon
Ph.D. Medicinal Chemistry/ Biochemistry | Florida International University | Miami, Florida

Post-graduate training
Florida International University | Miami, FL

Teaching Interests
Dr. Chbib’s teaching interests include various foundational science courses, such as Biochemistry, Medicinal Chemistry and Pharmacology.

Scholarly Interests
Dr. Chbib’s primary research goals are directed towards designing and synthesizing new chemical molecules with therapeutic activity. Her research interests are directed towards targeting the quorum sensing process in bacteria. Dr Chbib has published several original research manuscripts, abstracts and book chapters in the infectious diseases area and presented her research in multiple national organizations like the American Association of Pharmaceutical Sciences (AAPS). Dr Chbib’s research involves optimizing dissolution and quantification techniques of multiple drugs in blood/plasma samples using analytical techniques in her laboratory at LU. She is actively collaborating with the Vaccine Nanotechnology Laboratory and Center for Drug Delivery Research at Mercer University to evaluate the immune potency of new synthetic molecules for the development of new vaccines to prevent different types of infections.

Selected Publications:
• Chbib, C. Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. Bioorg. Med. Chem. 2020;28(3):115282. doi: 10.1016/j.bmc.2019.115282.
• Chbib C. Unexpected furanose-pyranose isomerization of 4-C-alkylfuranose. Carbohydr. Res. 2019;16;487:107879. doi:10.1016/j.carres.2019.107879. PMID:31759322.
• Chbib C. Synthesis of isomeric analogues of S-ribosylhomocysteine analogues with homocysteine unit attached to C2 of ribose. Bio. and Med. Chem. Lett. 2017;27:1681-1685
• Chbib C, Sobczak AJ, Mugdal M, Gonzales C, Lumpuy, D, Nagaj J, Stokowa-Soltys K, Wnuk SF. S-ribosylhomocysteine analogues modified at the ribosyl C-4 position. J. of Sulfur Chem. 2016;37:307-327.

Selected Recent Presentations
• Chbib C. Synthesis and biological evaluation of 2-fluoro-S-ribosylhomocysteine analogues, American Association of Pharmaceutical Scientists AAPS, November 4-7, 2018, Washington DC, US.
• Chbib C, Wnuk SF. Design and Synthesis of novel S-Ribosylhomocysteine analogues. 16th Annual World Preclinical Congress WPI October 2017, Boston, MA, US.

Certifications
Board certified pharmacist (Florida)
Board certified immunizer
Medication therapy management certificate
Veterinary pharmacy

Dr. Chbib’s primary research goals are directed towards designing and synthesizing new chemical molecules with therapeutic activity. Her research interests are directed towards targeting the quorum sensing process in bacteria. Dr Chbib has published several original research manuscripts, abstracts and book chapters in the infectious disease area and presented her research in multiple national organizations like the American Association of Pharmaceutical Sciences (AAPS). Dr Chbib was successful in designing and synthesizing nucleoside analogues constructed with chemically activated features to inactivate bacterial virulence. The two classes of analogues she synthesized, were found to exhibit concentration-dependent inhibition of las gene in P. aeruginosa and other bacteria. Dr Chbib’s research involves optimizing dissolution and quantification techniques of multiple drugs in blood/plasma samples using analytical techniques in her laboratory at LU. She is actively collaborating with the Vaccine Nanotechnology Laboratory and Center for Drug Delivery Research at Mercer University to evaluate the immune potency of new synthetic molecules for the development of new vaccines to prevent different types of infections.

  • Chbib, C. Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. Bioorg. Med. Chem. 2020;28(3):115282. doi: 10.1016/j.bmc.2019.115282.
  • Chbib C. Unexpected furanose-pyranose isomerization of 4-C-alkylfuranose. Carbohydr. Res. 2019;16;487:107879. doi:10.1016/j.carres.2019.107879. PMID:31759322.
  • Chbib C. Synthesis of isomeric analogues of S-ribosylhomocysteine analogues with homocysteine unit attached to C2 of ribose. Bio. and Med. Chem. Lett. 2017;27:1681-1685
  • Chbib C, Sobczak AJ, Mugdal M, Gonzales C, Lumpuy, D, Nagaj J, Stokowa-Soltys K, Wnuk SF. S-ribosylhomocysteine analogues modified at the ribosyl C-4 position. J. of Sulfur Chem. 2016;37:307-327.
  • Sobzak, A.; Chbib, C.; Wnuk, S.F. S-ribosylhomocysteine Analogues Containing a [4-Thio-Ribose Ring, Carbohyd. Res. 415: 39-47, 2015.
  • Saab Y.B.; Kabbara W.; Chbib C.; Gard P.R. Buccal Cell DNA Extraction: Yield, Purity, and Cost: A Comparison of Two Methods, Genet. test. 11: 413-416, 2007.