Thomas A. Edwards

Professor
Ph.D.
Office: room 2304
Phone: 305-760-7516
Email: TEdwards@ULarkin.org
Hours: By Appointment

Dr. Edwards has 20 years of experience in teaching and research in a University environment. Dr. Edwards has taught an array of undergraduate modules in Biochemistry and Biological Sciences and supervised 29 graduate students through to a Ph.D. He has been principal- or co-Investigator on grants focused on structural & chemical biology and virology worth >$16million and published 70 peer-reviewed manuscripts. At the University of Leeds (2005-2022) he served as Deputy Head of the School of Molecular and Cellular Biology (2018-2021); Deputy Director of the Astbury Centre for Structural Molecular Biology (2012-2018), and on the School Management Committee (2008 – 2022). Dr Edwards arrived at Larkin University in September 2022 to teach Biochemistry and Genetics.

Research Profile

Dr Edwards uses structural biology (mostly X-ray crystallography, but including EM and NMR) to study the structure and function of a variety of proteins.  He studies RNA binding proteins in development and disease and has recently focussed on RNA binding proteins from RNA viruses. Another focus is in investigating protein-protein interactions involved in the control of cancer.

70 publications, >3,000 citations, H-index = 32

Selected recent publications:

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site. KZ Haza, HL Martin, A Rao, AL Turner, SE Saunders, B Petersen, C Tiede,  Kevin Tipping, Anna A Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M Fishwick, Thomas L Adams, Thembaninkosi G Gaule, Chi H Trinh, Matthew Johnson, Alexander L Breeze, Thomas A Edwards, Michael J McPherson, Darren C Tomlinson (2021). Nature Communications 12 (1), 1-15

 

Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs. JA Miles, F Hobor, CH Trinh, J Taylor, C Tiede, PR Rowell, BR Jackson,  Fatima A Nadat, Pallavi Ramsahye, Hannah F Kyle, Basile IM Wicky, Jane Clarke, Darren C Tomlinson, Andrew J Wilson, Thomas A Edwards (2021). ChemBioChem 22 (1), 232-240

 

Structure of the 70S ribosome from the human pathogen acinetobacter baumannii in complex with clinically relevant antibiotics. D Nicholson, TA Edwards, AJ O’Neill, NA Ranson (2020). Structure 28 (10), 1087-1100. e3

 

The structure of the human respiratory syncytial virus M2-1 protein bound to the interaction domain of the phosphoprotein P defines the orientation of the complex. M Selvaraj, K Yegambaram, EJAA Todd, CA Richard, RL Dods, Georgia M Pangratiou, Chi H Trinh, Sophie L Moul, James C Murphy, Jamel Mankouri, Jean-François Éléouët, John N Barr, Thomas A Edwards (2018). mBio 9 (6), e01554-18

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions. GM Burslem, HF Kyle, A Nelson, TA Edwards, AJ Wilson (2017). Chemical science 8 (6), 4188-4202

ABC-F proteins mediate antibiotic resistance through ribosomal protection. LKR Sharkey, TA Edwards, AJ O’Neill (2016). mBio 7 (2), e01975-15

Selective and potent proteomimetic inhibitors of intracellular protein–protein interactions. A Barnard, K Long, HL Martin, JA Miles, TA Edwards, DC Tomlinson, Andrew Macdonald, Andrew J Wilson (2015). Angewandte Chemie 127 (10), 3003-3008

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. SJ Tanner, A Ariza, CA Richard, HF Kyle, RL Dods, ML Blondot, W Wu, José Trincão, Chi H Trinh, Julian A Hiscox, Miles W Carroll, Nigel J Silman, Jean-François Eléouët, Thomas A Edwards, John N Barr (2014). Proceedings of the National Academy of Sciences 111 (4), 1580-1585

Full publication list:

‪Thomas A. Edwards – ‪Google Scholar